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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Respiratory epithelial adenomatoid hamartomas of the sinonasal tract
G Mortuaire1, X Pasquesoone, X Leroy
1Department of Otorhinolaryngology, Head and Neck Surgery, Claude Huriez Hospital Pr Chevalier, University of Lille, CHRU Lille, Lille, France. mortuaire.g@club-internet.fr
Abstract:
We report the clinicopathologic features of two cases of respiratory epithelial adenomatoid harmartoma (REAH) of the sinonasal tract. Hamartomas are rare in the nasal cavity. Histologically, these lesions were characterized by a glandular proliferation lined by ciliated respiratory epithelium originated from the surface epithelium. The two patients were evaluated by a gastroenterologist to assess intestine colocalization. The treatment was a complete surgical resection through limited approach. We should be aware of this entity as a differential diagnosis for inverted papilloma and well-differenciated adenocarcinoma. Fine histopathological analysis is necessary to avoid aggressive surgery for this benign lesion.
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