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Platelet aggregation and P-selectin levels during exercise treadmill test in patients with ischaemic heart disease

Małgorzata Kobusiak-Prokopowicz1, Wiktor Kuliczkowski, Bozena Karolko

  • 1Katedra i Klinika Kardiologii Akademii Medycznej, ul. Pasteura 4, 50-367 Wrocław. kard@kard.am.wroc.pl

Kardiologia Polska
|November 8, 2006
PubMed

Insights

Physical exercise does not increase platelet aggregation in coronary artery disease (CAD) patients on aspirin. However, platelet activation, measured by P-selectin expression, increases during exercise despite aspirin therapy.

Area of Science:

  • Cardiology
  • Hematology
  • Exercise Physiology

Background:

  • Coronary artery disease (CAD) is linked to heightened platelet activation, even with aspirin.
  • Conflicting data exists on platelet activation during exercise in CAD patients on aspirin.

Purpose of the Study:

  • To evaluate platelet activation patterns in CAD patients during physical exercise.

Main Methods:

  • 35 CAD patients (CCS II) on 75 mg aspirin daily and 10 controls underwent treadmill testing (Bruce protocol).
  • Assessed platelet aggregation (ADP, collagen, arachidonic acid) and P-selectin expression (platelet and soluble) pre-exercise, peak exercise, and post-exercise.

Main Results:

  • No significant differences in collagen and ADP aggregation between groups.
  • ADP aggregation increased significantly at peak exercise in controls, not CAD patients.
  • Platelet P-selectin expression (unstimulated) was significantly higher in CAD patients 1 hour post-exercise.

Conclusions:

  • Physical exercise does not intensify platelet aggregation in CAD patients on daily aspirin.
  • Platelet activation, indicated by P-selectin expression, increases during exercise in CAD patients despite aspirin.
  • Soluble P-selectin concentration does not correlate with platelet P-selectin expression in CAD patients.
Abstract

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