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Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
Namphung Vongvanich1, Prasat Kittakoop, Panarat Charoenchai
1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Abstract:
Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 - 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity.
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