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Structure and function of latency-associated nuclear antigen

S C Verma1, K Lan, E Robertson

  • 1Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA. erle@mail.med.upenn.edu

Current Topics in Microbiology and Immunology
|November 9, 2006
PubMed
Summary

Latency-associated nuclear antigen (LANA) is crucial for KSHV pathogenesis, maintaining viral DNA persistence and potentially driving cancer by dysregulating cellular pathways. Its role in viral episome tethering to host chromosomes is key to KSHV persistence.

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