Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of latency-associated nuclear antigen.

S C Verma1, K Lan, E Robertson

  • 1Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA. erle@mail.med.upenn.edu

Current Topics in Microbiology and Immunology
|November 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The implementation of whole-genome sequencing for <i>Mycobacterium tuberculosis</i> in Vietnam.

IJTLD open·2024
Same author

Bypassing the post-anaesthesia care unit after elective hip and knee arthroplasty.

Anaesthesia·2023
Same author

Demographics and host-kill parameters of <i>Diglyphus horticola</i> Khan against <i>Chromatomyia horticola</i> (Goureau).

Bulletin of entomological research·2022
Same author

COVID-19: smoke testing of surgical mask and respirators.

Occupational medicine (Oxford, England)·2020
Same author

FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
Same author

Improving understanding of type 2 diabetes remission: research recommendations from Diabetes UK's 2019 remission workshop.

Diabetic medicine : a journal of the British Diabetic Association·2020

Latency-associated nuclear antigen (LANA) is crucial for KSHV pathogenesis, maintaining viral DNA persistence and potentially driving cancer by dysregulating cellular pathways. Its role in viral episome tethering to host chromosomes is key to KSHV persistence.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Latency-associated nuclear antigen (LANA) is a key protein encoded by KSHV's ORF73.
  • LANA is essential for KSHV-associated malignancies and viral latency.
  • It interacts with numerous viral and cellular proteins.

Purpose of the Study:

  • To elucidate the multifaceted roles of LANA in KSHV pathogenesis.
  • To understand LANA's function in maintaining viral DNA persistence and oncogenesis.

Main Methods:

  • The study reviews LANA's known interactions and functions.
  • Analysis of LANA's role in cellular pathway dysregulation (pRb, p53, Wnt signaling).
  • Investigation of LANA's mechanism in tethering viral DNA to host chromosomes.

Related Experiment Videos

Main Results:

  • LANA dysregulates tumor suppressor pathways (pRb, p53) and transforms cells with Hras.
  • It modulates Wnt signaling via GSK-3beta, increasing beta-catenin.
  • LANA blocks RTA expression, maintaining viral latency, and tethers viral DNA to host chromosomes for episome partitioning.

Conclusions:

  • LANA is a critical oncogenic protein in KSHV pathogenesis.
  • Its functions in viral DNA tethering and latency maintenance are vital for KSHV persistence.
  • LANA plays a central role in KSHV-mediated disease progression.