Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adventures in high-altitude physiology.

John B West1

  • 1Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0623, USA. jwest@ucsd.edu

Advances in Experimental Medicine and Biology
|November 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Alveolar Gas Monitor: An Alternative to Pulse Oximetry for the Noninvasive Assessment of Impaired Gas Exchange in Patients at Risk of Respiratory Deterioration.

Journal of clinical medicine·2025
Same author

Noninvasive Assessment of Impaired Gas Exchange with the Alveolar Gas Monitor Predicts Clinical Deterioration in COVID-19 Patients.

Journal of clinical medicine·2023
Same author

Time Domains of Hypoxia Responses and -Omics Insights.

Frontiers in physiology·2022
Same author

The strange history of atmospheric oxygen.

Physiological reports·2022
Same author

Elevating physiology: Griffith Pugh on the limits of human performance and survival.

The Journal of physiology·2022
Same author

Inspired oxygen: present, past, and future.

American journal of physiology. Lung cellular and molecular physiology·2021
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

This research explores high-altitude physiology and medicine, detailing extreme measurements on Mount Everest and Makalu. It investigates the causes of high-altitude pulmonary edema and oxygen enrichment strategies for high-altitude environments.

Area of Science:

  • High-altitude physiology and medicine
  • Extreme environment research
  • Pulmonary medicine

Background:

  • Decades of research in high-altitude physiology, including expeditions to 5800m near Everest and 7440m on Makalu.
  • Pioneering physiological measurements at extreme altitudes, including VO2max (maximal oxygen uptake).
  • Historical context of early high-altitude expeditions and their scientific contributions.

Discussion:

  • Findings from the 1981 American Medical Research Expedition to Everest, including summit physiological data.
  • Extraordinary measurements: low alveolar PCO2 (7-8 mmHg), high arterial pH (>7.7), and low VO2max (~1 L/min).
  • Exploration of the pathogenesis of high-altitude pulmonary edema, proposing 'stress failure' of pulmonary capillaries due to hypoxic vasoconstriction.

Key Insights:

Related Experiment Videos

  • Understanding the physiological limits and adaptations of the human body at extreme altitudes.
  • Identifying potential causes of severe altitude-related illnesses like pulmonary edema.
  • Demonstrating the feasibility and benefits of oxygen enrichment in high-altitude living and working spaces.

Outlook:

  • Continued research into high-altitude pulmonary edema and its prevention/treatment.
  • Implementation of oxygen enrichment technologies in high-altitude observatories and habitats.
  • Establishment of an international archive for high-altitude medicine and physiology research.