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Related Experiment Videos

The eye at altitude.

Daniel S Morris1, John Somner, Michael J Donald

  • 1Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. danielsmorris@hotmail.com

Advances in Experimental Medicine and Biology
|November 9, 2006
PubMed
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High altitude retinopathy (HAR) affects lowlanders above 2500m, causing retinal vessel engorgement and potential vision issues. Research informs advice for travelers and may offer insights into treating diabetic retinopathy.

Area of Science:

  • Ophthalmology
  • Altitude Medicine
  • Physiology

Background:

  • High altitude retinopathy (HAR) involves retinal vein engorgement and potential hemorrhages, first described in 1969.
  • Recent studies confirm retinal vascular changes in lowlanders above 2500m, including corneal and intraocular pressure alterations.
  • The retina's vasculature is uniquely observable and crucial for oxygen-demanding photoreceptors.

Purpose of the Study:

  • To investigate retinal vascular and functional changes under hypobaric hypoxia.
  • To provide evidence-based advice for lowlanders traveling to altitude, especially those with pre-existing ocular conditions or undergoing refractive surgery.
  • To explore potential therapeutic links between retinal hypoxia responses and diabetic retinopathy.

Main Methods:

Related Experiment Videos

  • Utilizing hypobaric chambers and field expeditions to simulate high-altitude conditions.
  • Observing changes in retinal vasculature, corneal thickness, and intraocular pressure.
  • Applying new techniques to monitor retinal function during hypobaric hypoxia.

    • Main Results:

    • Confirmed retinal vasculature engorgement and tortuosity above 2500m in lowlanders.
    • Documented changes in corneal thickness and intraocular pressure at altitude.
    • Identified pathological states including hemorrhages, cotton wool spots, and papilledema.

    Conclusions:

    • Understanding HAR aids in advising travelers and managing altitude-related visual problems.
    • Research on retinal response to hypobaric hypoxia may inform treatments for retinal hypoxia-related blindness, such as diabetic retinopathy.