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Paget's disease from Western India.

Shashank R Joshi¹, S Ambhore, N Butala

¹Lilavati and Bhatia Hospital, Mumbai.

The Journal of the Association of Physicians of India

|November 9, 2006

Summary

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Paget

Area of Science:

Bone Metabolism and Disease
Epidemiology of Skeletal Disorders

Background:

Paget's disease of bone is a chronic condition affecting bone remodeling.
Understanding its prevalence in diverse geographic regions is crucial.

Purpose of the Study:

To investigate the prevalence and characteristics of Paget's disease in Western India.
To analyze clinical, biochemical, and skeletal profiles of affected individuals.

Main Methods:

Prospective study of 17 consecutive cases from Western India (1998-2005).
Analysis of clinical presentation, biochemical markers (alkaline phosphatase), and skeletal involvement.
Evaluation of treatment response to bisphosphonates, specifically alendronate.

Main Results:

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Paget's disease in Western India presents with male preponderance (15 males, 2 females) and a mean age of 62.
Common symptoms include pain, fractures, and involvement of pelvis, skull, spine, and femur.
Elevated alkaline phosphatase levels responded well to low-dose alendronate therapy within 6 months.

Conclusions:

Paget's disease is rare in Western India but exhibits classical clinical, radiological, and biochemical features.
The condition is non-familial and polyostotic.
Low-dose alendronate is an effective treatment for Paget's disease in this cohort.