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Following the Dynamics of Structural Variants in Experimentally Evolved Populations
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Will population bottlenecks and multilocus epistasis increase additive genetic variance?

Michael Turelli1, N H Barton

  • 1Section of Evolution and Ecology, University of California, Davis, California 95616, USA. mturelli@ucdavis.edu

Evolution; International Journal of Organic Evolution
|November 9, 2006
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Population bottlenecks rarely increase additive genetic variance due to epistasis in realistic models. High inbreeding levels are necessary for significant genetic variance conversion, challenging previous findings.

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Area of Science:

  • Evolutionary genetics
  • Quantitative genetics

Background:

  • Population bottlenecks can alter genetic variance, impacting evolutionary potential.
  • Epistasis (gene interactions) is hypothesized to increase additive genetic variance after bottlenecks.

Purpose of the Study:

  • To analytically investigate the consequences of population bottlenecks on expected additive genetic variance.
  • To evaluate the role of multilocus epistasis in increasing additive variance.

Main Methods:

  • Application of new analytical methods to theoretical models of multilocus epistasis.
  • Re-evaluation of previously simulated models demonstrating increased additive variance after bottlenecks.

Main Results:

  • Large increases in expected additive genetic variance due to epistasis are unlikely in biologically plausible models.
  • Previous findings of increased variance with more loci are attributed to unrealistic model assumptions (e.g., high-order epistasis).
  • Conversion of nonadditive to additive variance depends on variance components, not solely the number of loci.

Conclusions:

  • Epistasis is unlikely to be a major driver of increased additive genetic variance following population bottlenecks in realistic scenarios.
  • Significant conversion of genetic variance requires high inbreeding levels (F > 0.5).
  • Alternative modeling approaches for multilocus epistasis are needed.