Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base
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Updated: Jul 19, 2026
Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme
Published on: April 12, 2013
1Department of Biomedicine, University of Bergen, Bergen, Norway. Xuguang.Nie@biomed.uib.no
Objective:
To examine the expression pattern of the Fgf and Msx genes in cranial base development.
Materials And Methods:
To detect the expression of these genes, antisense riboprobes were synthesized by in vitro transcription. Radioactive in situ hybridization was performed on parasagittal sections of embryonic mouse heads.
Results:
Msx2 was observed in the underlying perichondrium at restricted stages. Msx1 was not observed in cranial base development. Fgf1 was localized in osteogenic cells from the time of ossification; Fgf10 was highly expressed in the occipital-vertebral joint during E13 to E14; Fgf2, Fgf7, and Fgf18 were localized in the perichondria; Fgf12 was transitorily expressed at early chondrocranium; Fgf9 was seen in the hypertrophic chondrocytes.
Conclusions:
The Fgf and Msx gene expression in the cranial base was different from that of other skeletons.
