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Updated: Jul 19, 2026

A Rat Model of Compound Acne
Published on: November 1, 2024
Clinical inquiries. What is the best treatment for mild to moderate acne?
Shobha Rao1, Mehreen A Malik, Laura Wilder
1University of Texas Southwestern Family Practice Residency, Dallas, TX, USA.
Abstract:
For mild comedonal acne, monotherapy with topical retinoids is the treatment of choice (strength of recommendation [SOR]: A). For moderate comedonal and mild to moderate papulopustular acne, combination therapy with either benzoyl peroxide or topical retinoids (adapalene [Differin], tazarotene [Tazorac], tretinoin [Retin-A]) plus topical antibiotics (erythromycin or clindamycin) is proven most effective (SOR: A). Six to 8 weeks should be allowed for most treatments to work before altering the regimen (SOR: A).
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