Related Experiment Videos
Protein oxidation and degradation during aging: role in skin aging and neurodegeneration
Rebecca Widmer1, Isabella Ziaja, Tilman Grune
1Research Institute of Environmental Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Abstract:
During aging, the products of oxidative processes accumulate and might disturb cellular metabolism. Among them are oxidized proteins and protein aggregates. On the other hand, in a functioning metabolic system oxidized proteins are degraded, mainly by the proteasome. During aging, however, proteasome activity declines. Therefore, the ability to degrade oxidized proteins is attenuated. The following review summarises the accumulation of oxidized proteins and the decline of the proteasomal system during skin and brain aging including some age-related neurodegenerative processes. The role of protein aggregates will be discussed as a potential reason for the accelerated dysfunction of tissue during aging.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Radical Autoxidation
The Effect of Aging on Tissues
Mitochondria
Alzheimer Disease l: Introduction
Parkinson Disease ll: Pathophysiology