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The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

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Related Experiment Video

Updated: Jul 19, 2026

Original Experimental Approach for Assessing Transport Fuel Stability

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Published on: October 21, 2016

Clinical oxidation parameters of aging.

Peter Voss¹, Werner Siems

¹Research Institute for Environmental Medicine, Molecular Aging Research, Heinrich Heine University Duesseldorf, D-40225, Duesseldorf, Germany.

Free Radical Research

|November 9, 2006

Summary

Oxidative stress biomarkers, like lipid peroxidation (LPO) and protein oxidation, are crucial for understanding aging. A comprehensive panel of biomarkers, not just one, is needed to accurately assess biological age and health status.

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Area of Science:

Gerontology and Oxidative Stress Research
Biomarker Discovery for Aging

Background:

Aging is a complex physiological process involving progressive decline and increased susceptibility to oxidative stress throughout life.
Numerous substances, including lipid peroxidation (LPO) products, protein oxidation products, and antioxidants, have been proposed as biomarkers for aging and oxidative stress.

Purpose of the Study:

To evaluate the utility of various biomarkers in assessing oxidative stress during aging.
To determine the feasibility of using single biomarkers for predicting life expectancy or biological age.
To advocate for a multi-biomarker approach for a comprehensive assessment of oxidation status.

Main Methods:

Review of existing literature on oxidative stress biomarkers in aging.
Analysis of conflicting data regarding individual biomarker changes during the aging process.
Identification of key biomarker categories for a comprehensive assessment.

Main Results:

No single biomarker has achieved universal acceptance for determining life expectancy or age-related health status.
Conflicting data exists for many individual biomarkers, influenced by various external factors.
A single marker is insufficient due to multifactorial influences on concentration and activity.

Conclusions:

A single clinical marker cannot reliably determine an individual's health or predict life expectancy.
A comprehensive set or pattern of clinical biomarkers is essential for accurately assessing a person's oxidation status.
Recommended biomarker sets should include markers for LPO, protein oxidation, total antioxidative status, and ideally DNA damage.