Related Experiment Video
Updated: Jul 19, 2026
Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
Published on: October 21, 2022
Evidence for the presence of lipofibroblasts in human lung
Virender K Rehan1, Sharon Sugano, Ying Wang
1Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA, David Geffen School of Medicine, University of California, Los Angeles, California 90502, USA. vrehan@labiomed.org
Abstract:
The lipid-containing alveolar interstitial fibroblast (lipofibroblast) is known to be critically involved in rodent lung development, homeostasis, and injury/repair. However, there is lack of information on their presence and function in the human lung. Based on a number of morphological (lipid staining), molecular (presence of characteristic lipogenic and absence of myogenic markers), and functional (triglyceride uptake) characteristics that are the hallmarks of the rodent lung lipofibroblast, using human lung fibroblasts of embryonic (WI-38) and adult origin and lung tissue from human autopsy specimens, the authors for the first time clearly demonstrate the presence of lipofibroblasts in the human lung.
