Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping the evidence on anaemia across trimesters of pregnancy and risk of adverse birth outcomes in sub-Saharan Africa: a scoping review protocol.

BMJ openยท2026
Same author

New Zealand Electronic Health Data for Cardiovascular Research: A Review.

Clinical epidemiologyยท2026
Same author

Statin use in patients with coronary atheroma identified on computed tomography coronary angiography: current practice in South Auckland, New Zealand (ANZACS-QI 82).

The New Zealand medical journalยท2026
Same author

Declining Incidence of Atrial Fibrillation-Associated Ischemic Stroke in Auckland, New Zealand (2012 Versus 2021).

Journal of the American Heart Associationยท2026
Same author

A population-based study of traumatic brain injury incidence and mechanisms in New Zealand: 2021-2022 compared with 2010-2011.

The Lancet regional health. Western Pacificยท2026
Same author

Considerations for study design and analysis for ethically and culturally safe DNA methylation research in Aotearoa New Zealand.

SSM - population healthยท2025

Related Experiment Video

Updated: Jul 19, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Longitudinal left ventricular contractile dysfunction after exercise in aortic stenosis.

Niels C Van Pelt1, Ralph A H Stewart, Malcolm E Legget

  • 1Department of Cardiology, Middlemore Hospital, Auckland, New Zealand.

Heart (British Cardiac Society)
|November 9, 2006
PubMed
Summary

A reduced increase in mitral annular velocity after exercise indicates early left ventricular dysfunction in patients with moderate-to-severe aortic stenosis. This Doppler tissue imaging (DTI) finding helps identify subclinical systolic dysfunction.

More Related Videos

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jul 19, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • Aortic stenosis (AS) can lead to left ventricular (LV) dysfunction.
  • Early detection of LV dysfunction in asymptomatic AS patients is crucial for timely intervention.
  • Conventional measures may not detect subtle functional changes in early stages.

Purpose of the Study:

  • To assess if post-exercise Doppler tissue imaging (DTI) can identify early LV systolic dysfunction in asymptomatic patients with moderate-to-severe AS.
  • To correlate DTI-derived parameters with exercise capacity and B-type natriuretic peptide (BNP) levels.

Main Methods:

  • A case-control study involving 20 patients with moderate-to-severe AS and 15 age-matched controls.
  • Echocardiography with DTI performed at rest and immediately after treadmill exercise.
  • Measured peak systolic velocity of the lateral mitral annulus (S'), exercise capacity, systolic blood pressure response, and plasma BNP levels.

Main Results:

  • At rest, S' was similar between AS patients and controls.
  • After exercise, AS patients showed significantly lower S' and a smaller increase in S' compared to controls.
  • A diminished post-exercise S' increase correlated with reduced exercise capacity, blunted systolic blood pressure response, and elevated BNP levels in AS patients.

Conclusions:

  • A blunted increase in peak systolic mitral annular velocity (S') after treadmill exercise is a sensitive marker of early LV systolic dysfunction in asymptomatic patients with moderate-to-severe AS.
  • Post-exercise DTI is valuable for detecting subclinical LV dysfunction in this population.
  • These findings support the use of DTI for risk stratification and management decisions in AS.