Diabetes known or newly detected, but not impaired glucose regulation, has a negative influence on 1-year outcome in
Mattie Lenzen1, Lars Ryden, John Ohrvik
1Thoraxcenter, Department of Cardiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
European Heart Journal
|November 9, 2006
Summary
Patients with coronary artery disease (CAD) and newly diagnosed diabetes face intermediate mortality risk. Impaired glucose regulation (IGR) did not independently predict adverse outcomes in this population.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Diabetes mellitus is a significant risk factor for cardiovascular diseases (CVDs) and predicts poor outcomes in patients with coronary artery disease (CAD).
- Limited data exists on the prognosis of CAD patients with newly diagnosed diabetes or impaired glucose regulation (IGR).
Purpose of the Study:
- To investigate the 1-year outcomes in patients with coronary artery disease (CAD) across different glucometabolic states.
- To assess the prognostic value of newly diagnosed diabetes and impaired glucose regulation (IGR) in CAD patients.
Main Methods:
- Utilized data from the Euro Heart Survey on diabetes and the heart, analyzing 4676 patients.
- Glucometabolic state was determined using oral glucose tolerance tests (OGTT) or fasting plasma glucose.
- 1-year mortality risk was compared between groups with normal glucose metabolism, IGR, and diabetes (previously diagnosed and newly diagnosed).
Main Results:
- Previously diagnosed diabetes (HR 2.4) and newly diagnosed diabetes (HR 2.0) were associated with increased 1-year mortality compared to normal glucose regulation.
- Impaired glucose regulation (IGR) was not identified as an independent predictor of 1-year mortality (HR 1.1).
- A total of 736 patients could not be classified due to insufficient glucose testing data.
Conclusions:
- Patients with CAD and known diabetes exhibit high mortality risk.
- Newly diagnosed diabetes in CAD patients presents an intermediate risk for adverse outcomes.
- Impaired glucose regulation (IGR) did not independently predict adverse outcomes within the 1-year follow-up period.
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