Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neurokinin A and B.

¹Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

|January 1, 1991

Summary

This summary is machine-generated.

This study details the chemical, pharmacological, and biochemical properties of new mammalian tachykinin peptides, neurokinin A and neurokinin B. These novel peptides are compared to substance P, a known member of the tachykinin family.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Elucidation of structural requirements of mastoparan for mast cell activation-toward the comprehensive prediction of cryptides acting on mast cells.

Protein and peptide letters·2008

Same author

Antibacterial activity and clinical efficacy of sparfloxacin in Mycobacterium avium-intracellulare complex infection.

The Journal of international medical research·2004

Same author

Transcriptional regulation of interferon gamma gene by p300 co-activator.

Nucleic acids research. Supplement (2001)·2003

Same author

[Clinical utility and safety of diagnostic thoracoscopy].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society·2002

Same author

Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells.

Biomacromolecules·2002

Same author

Chemo-enzymatic synthesis of a bioactive peptide containing a glutamine-linked oligosaccharide and its characterization.

Biochimica et biophysica acta·2001

Same journal

Pharmacokinetics of triclabendazole in rabbits.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

Same journal

Characterization of the alpha 1B-adrenergic receptors of chicken hepatocytes. Signal transduction and actions.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

Same journal

Evolution of neuropeptide Y and its related peptides.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

Same journal

Binding of agonists and antagonists to the porcine adipose tissue beta-adrenergic receptor(s).

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

Same journal

Effect of diflubenzuron on incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the intact integument from the newly molted American cockroach Periplaneta americana.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

Same journal

Effect of diflubenzuron on the incorporation of UDP-N-acetyl-[3H]glucosamine (UDP-[3H]NAGA) to chitin in permeabilized, and isolated integuments from the newly molted American cockroach Periplaneta americana.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1993

See all related articles

Area of Science:

Biochemistry
Pharmacology
Neuroscience

Background:

Tachykinins are a family of peptides involved in various physiological processes.
Substance P is a well-characterized member of the tachykinin family.
Novel tachykinin peptides have been identified in mammals.

Purpose of the Study:

To describe the chemical features of neurokinin A and neurokinin B.
To characterize the pharmacological and biochemical properties of neurokinin A and neurokinin B.
To compare these novel peptides with substance P.

Main Methods:

Chemical analysis of neurokinin A and neurokinin B.
Pharmacological assays to determine activity.
Biochemical characterization of peptide properties.

Related Experiment Videos

Main Results:

Detailed chemical structures of neurokinin A and neurokinin B elucidated.
Pharmacological profiles of neurokinin A and neurokinin B established.
Biochemical characteristics compared to substance P.

Conclusions:

Neurokinin A and neurokinin B represent novel mammalian tachykinins.
These peptides share similarities and differences with substance P.
Further research into their physiological roles is warranted.