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Updated: Jul 19, 2026
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Allograft-prosthesis composites after bone tumor resection at the proximal tibia
David Jean Biau1, Valérie Dumaine, Antoine Babinet
1Service de Chirurgie Orthopédique et Traumatologie B, Hôpital Cochin, AP-HP, Paris Université V, Paris, France. djmbiau@yahoo.fr
Clinical Orthopaedics and Related Research
|November 9, 2006
Summary
Irradiated allograft-prosthesis composites show poor survival for proximal tibia reconstruction. Complications like fracture, resorption, and infection are common, leading to a recommendation against their use.
Area of Science:
- Orthopedic Surgery
- Oncology
- Biomaterials Science
Background:
- Allograft-prosthesis composites (APCs) are used in reconstructions, but their efficacy at the proximal tibia is unclear.
- Previous studies suggest APCs benefit other reconstruction sites.
- Conventional megaprostheses are an alternative for proximal tibia reconstruction.
Purpose of the Study:
- To evaluate the survival and outcomes of irradiated allograft-prosthesis composites (APCs) in proximal tibia reconstruction.
- To compare APCs with conventional megaprostheses for extensor mechanism reattachment and survival.
- To identify complications associated with irradiated APCs in this specific anatomical location.
Main Methods:
- Retrospective review of 26 patients undergoing proximal tibia tumor resection and reconstruction with APCs.
- Use of Guepar massive custom-made fully constrained prostheses with gamma-radiation-sterilized allografts.
- Cemented stem fixation into allograft and host bone, with a minimum 6-month follow-up (median 128 months).
Main Results:
- Median APC survival was 102 months, but 14 patients required component removal.
- Complications included allograft fracture (7/26), resorption (6/26), infection (6/26), and extensor mechanism failure (6/26).
- Seven allografts showed signs of host bone fusion, indicating potential for biological integration.
Conclusions:
- Irradiated allograft-prosthesis composites demonstrate a high rate of complications and failures in proximal tibia reconstruction.
- The observed poor outcomes do not support the use of gamma-radiation-sterilized APCs for this specific surgical application.
- Further research may be needed to explore alternative materials or techniques for proximal tibia reconstruction after tumor resection.
