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Gene-environment interactions differentially affect mouse strain behavioral parameters.

Valter Tucci1, Heena V Lad, Andy Parker

  • 1MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|November 9, 2006
PubMed
Summary
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Subtle changes in mouse housing environments significantly impact behavioral test results, revealing genotype-environment-test interactions. Standardized recording of environmental variables is crucial for accurate interpretation in behavioral and functional genomics studies.

Area of Science:

  • Genetics
  • Neuroscience
  • Animal Behavior

Background:

  • Systematic phenotyping of mouse strains is essential for functional genetic information.
  • Standardized phenotyping protocols, like EMPReSS, ensure data consistency across labs and time.
  • Neurologic and behavioral screens are critical components of phenotyping, especially for mutagenesis screens.

Purpose of the Study:

  • To investigate the impact of subtle variations in mouse cage environment on behavioral test outcomes.
  • To identify genotype-environment-test interactions in behavioral assays.
  • To assess the necessity of systematically recording environmental variables in behavioral studies.

Main Methods:

  • Cross-validated screening batteries were used in commonly used inbred mouse strains.

Related Experiment Videos

  • Subtle changes in cage enrichment were systematically introduced.
  • Behavioral outcomes, including open-field test and prepulse inhibition of acoustic startle response, were recorded.

    • Main Results:

    • Significant and distinct genotype-environment-test interactions were identified.
    • Strain order in open-field entries and distance traveled was reversed by different enrichment forms.
    • Prepulse inhibition of acoustic startle response was quantitatively unaffected by enrichment conditions.

    Conclusions:

    • Subtle environmental variations can lead to data misinterpretation in behavioral studies if not systematically recorded.
    • The influence of environmental variables on behavioral outcomes may be behavior-specific.
    • Further research on genetic and environmental variables is critical for advancing behavioral and functional genomics.