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Published on: January 2, 2012
Free radical-scavenging delta-lactones from Boletus calopus
Jin-Woo Kim1, Ick-Dong Yoo, Won-Gon Kim
1Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Abstract:
The methanol extracts from the fruiting body of the mushroom Boletus calopus showed free radical-scavenging activity. Bioactivity-guided fractionation of the methanol extracts led to a new hydroxylated calopin named calopin B, along with the known delta-lactones calopin and cyclocalopin A. The structure of the new calopin analogue was elucidated by spectroscopic methods. All compounds showed potent free radical-scavenging activity against superoxide, DPPH, and ABTS radicals with IC (50) values of 1.2 - 5.4 microg/mL.
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