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Tracking oxytetracyline mobility across environmental interfaces by second harmonic generation.

Amanda L Mifflin1, Christopher T Konek, Franz M Geiger

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

The Journal of Physical Chemistry. B
|November 10, 2006
PubMed
Summary
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This study shows that the antibiotic oxytetracycline (OTC) binds to surfaces at pH 8, influenced by pH and surface type. This impacts environmental transport and antibiotic resistance.

Area of Science:

  • Environmental Science
  • Chemistry
  • Microbiology

Background:

  • Antibiotic contamination in the environment is a growing concern.
  • Understanding antibiotic-surface interactions is crucial for predicting environmental fate.
  • Oxytetracycline (OTC) is a widely used antibiotic with potential environmental impacts.

Purpose of the Study:

  • To investigate the binding behavior of oxytetracycline (OTC) to various mineral oxide/water interfaces.
  • To determine the influence of pH and organic functional groups on OTC adsorption.
  • To elucidate the mechanisms governing OTC-interface interactions.

Main Methods:

  • Utilized second harmonic generation (SHG), an interface-specific technique.
  • Examined OTC binding to fused quartz, methyl ester, carboxylic acid, and alkyl interfaces.

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  • Conducted adsorption isotherm measurements and analyzed pH-dependent binding.

    • Main Results:

    • OTC binding was fully reversible and highly pH-dependent, with significant adsorption only at pH 8.
    • Polar organic-functionalized surfaces showed the highest relative surface coverage at pH 8.
    • Surface saturation was observed at 2 x 10(-5) M for the methyl ester-functionalized fused quartz/water interface.
    • Adsorption is controlled by hydrogen bonding and hydrophobic interactions, with free energies around -40 kJ/mol.

    Conclusions:

    • OTC environmental transport is significantly influenced by soil pH and composition.
    • The findings have implications for understanding and mitigating the development of bacterial antibiotic resistance.
    • Surface interactions play a key role in the environmental fate and bioavailability of OTC.