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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontal infection profiles in type 1 diabetes
Evanthia Lalla1, Selma Kaplan, Shu-mei J Chang
1Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA. EL94@columbia.edu
Journal of Clinical Periodontology
|November 10, 2006
Summary
Type 1 diabetes patients and controls had similar subgingival bacteria and antibody responses when periodontal disease severity was controlled. Cardiovascular risk markers differed between groups.
Area of Science:
- Periodontology
- Endocrinology
- Immunology
Background:
- Type 1 diabetes is linked to increased cardiovascular risk and altered immune responses.
- Periodontal disease is a common complication, potentially influenced by diabetes.
Purpose of the Study:
- To compare subgingival plaque bacteria and serum IgG responses in type 1 diabetes patients versus non-diabetic controls.
- To assess if differences persist after controlling for periodontal disease severity.
Main Methods:
- Matched cohort study of 50 type 1 diabetes patients and 50 controls with similar periodontal status.
- Analysis of 12 subgingival bacterial species and homologous serum IgG titres using checkerboard techniques.
- Measurement of serum cytokines and cardiovascular risk markers in a subset.
Main Results:
- No significant differences in IgG titres between groups.
- Only Eubacterium nodatum levels were higher in diabetic patients.
- Diabetic patients showed elevated soluble E-selectin, VCAM-1, adiponectin, and lower PAI-1.
Conclusions:
- Subgingival infection patterns and antibody responses are comparable between type 1 diabetes patients and controls when periodontal disease is matched.
- Elevated cardiovascular risk markers in type 1 diabetes patients warrant further investigation in relation to periodontal health.
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