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Updated: Jun 30, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

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Published on: November 23, 2014

Role of angiogenesis in the response to anticancer therapies

B A Teicher1

  • 1Lilly Research Laboratories, Lilly Corporate Cencer, Indianapolis, IN 46285, USA. TEICHER_BEVERLY_A@Lilly.com

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|November 10, 2006
PubMed

Insights

Antiangiogenic therapy, combined with chemotherapy, did not shrink tumors but enhanced drug delivery and improved treatment response in Lewis lung tumors. This suggests potential for combined antiangiogenic and cytotoxic cancer therapies.

Area of Science:

  • Oncology
  • Tumor Biology
  • Angiogenesis Research

Background:

  • Solid tumors require angiogenesis (new blood vessel formation) for growth.
  • Antiangiogenic agents can inhibit tumor vascularization.
  • The compatibility of antiangiogenic therapy with conventional treatments is under investigation.

Purpose of the Study:

  • To evaluate the combined effects of antiangiogenic agents (TNP-470/minocycline) with radiation and chemotherapy.
  • To determine if antiangiogenic therapy impacts tumor response to cytotoxic treatments.

Main Methods:

  • Lewis lung tumor model was used.
  • Tumors were treated with TNP-470 and minocycline, alongside radiation therapy and chemotherapy.

Main Results:

  • Antiangiogenic therapy alone did not affect tumor size.
  • Combined treatment significantly increased drug delivery to the tumor.
  • Tumor response to cytotoxic therapy was enhanced.

Conclusions:

  • Antiangiogenic agents like TNP-470/minocycline may improve the efficacy of chemotherapy and radiation.
  • These agents show potential for enhancing solid tumor treatment by improving drug delivery.

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