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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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Related Experiment Video

Updated: Jul 19, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Amyloidosis-associated kidney disease.

Laura M Dember1

  • 1Renal Section, Boston University School of Medicine, EBRC 504, 650 Albany Street, Boston, MA 02118, USA. ldember@bu.edu

Journal of the American Society of Nephrology : JASN
|November 10, 2006
PubMed
Summary

Amyloidosis involves protein misfolding and extracellular deposition, often affecting the kidney. Understanding these processes drives new treatments for organ dysfunction caused by amyloidosis.

Area of Science:

  • Nephrology
  • Pathology
  • Biochemistry

Background:

  • Amyloidosis encompasses disorders characterized by extracellular deposition of misfolded proteins as insoluble fibrils.
  • The kidney is a primary target organ in several types of amyloidosis, including AL, AA, and hereditary forms.
  • Protein misfolding and subsequent aggregation into amyloid fibrils lead to progressive organ dysfunction.

Purpose of the Study:

  • To review the pathogenesis, diagnosis, clinical manifestations, and treatment of amyloidoses.
  • To emphasize the significant renal aspects of amyloidosis across these domains.

Main Methods:

  • Review of existing literature on amyloidosis.
  • Focus on mechanisms of amyloid fibril formation, deposition, and tissue injury.

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Whole-Kidney Three-Dimensional Staining with CUBIC
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Whole-Kidney Three-Dimensional Staining with CUBIC

Published on: July 18, 2022

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Last Updated: Jul 19, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Whole-Kidney Three-Dimensional Staining with CUBIC
04:31

Whole-Kidney Three-Dimensional Staining with CUBIC

Published on: July 18, 2022

  • Analysis of diagnostic criteria and therapeutic strategies.

    • Main Results:

    • Amyloid fibril formation involves misfolding, self-aggregation into protofilaments, and subsequent fibril assembly.
    • Characteristic features include electron microscopic appearance and Congo red birefringence.
    • Advances in understanding pathogenesis have spurred novel treatment approaches.

    Conclusions:

    • Amyloidosis pathogenesis involves a complex cascade from protein misfolding to organ damage.
    • Comprehensive understanding is crucial for effective diagnosis and management, particularly concerning renal involvement.
    • Emerging therapeutic strategies offer improved outcomes for patients with amyloidosis.