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Related Experiment Video

Updated: Jul 19, 2026

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system.

Rosalind S E Carney¹, Teresa B Alfonso, Daniela Cohen

¹Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|November 10, 2006

Summary

The lateral cortical stream (LCS) arises from the corticostriatal border during development. This study reveals distinct cell origins and migratory patterns within the LCS, highlighting the crucial role of the Gsh2 gene in its formation.

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Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

The lateral cortical stream (LCS) is a crucial migratory pathway during brain development, originating from the corticostriatal border (CSB).
The LCS comprises diverse neural progenitor cells migrating to form key basal telencephalon structures like the piriform cortex and amygdala.

Purpose of the Study:

To investigate the timing, cellular composition, migratory behaviors, and genetic requirements of LCS development.
To elucidate the role of the transcription factor Gsh2 (genomic screened homeobox 2) in LCS formation.

Main Methods:

Employed a combination of in vitro and in vivo experimental approaches.
Utilized genetic markers such as Pax6 and Dlx2 to distinguish cell populations.
Analyzed cell origins, migratory routes, and gene dependencies.

Main Results:

Identified distinct temporal windows for the generation of Pax6-positive (pallial) and Dlx2-positive (subpallial) LCS progenitor cells.
Revealed the CSB as a source of both distinct and co-expressing Pax6/Dlx2 progenitor populations.
Demonstrated that Dlx2-positive cells exhibit chain-like migration and are generated locally at the CSB.
Established that LCS generation is dependent on the homeobox gene Gsh2.

Conclusions:

The development of the LCS involves temporally regulated, distinct progenitor populations originating from the CSB.
Gsh2 plays a novel and essential role in the formation of the LCS and overall telencephalic development.