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Related Experiment Video

Updated: Jul 19, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

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Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression.

Jacqueline K Rose¹, Catharine H Rankin

¹Department of Psychology and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|November 10, 2006

Summary

Memory recall can make memories unstable, requiring reconsolidation for retention. This study shows that habituation memory in C. elegans also needs reconsolidation, involving glutamate receptors, to be maintained.

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Area of Science:

Neuroscience
Molecular Biology
Behavioral Science

Background:

Consolidated memories can become labile upon reactivation, undergoing reconsolidation for later recall.
Memory reconsolidation is crucial for long-term memory retention but its mechanisms are not fully understood.

Purpose of the Study:

To investigate memory reconsolidation in a nonassociative learning task (habituation) in Caenorhabditis elegans.
To identify cellular mechanisms underlying memory reconsolidation in C. elegans.

Main Methods:

Habituation training and memory recall tests in adult C. elegans.
Disruption of memory reconsolidation using heat shock (inhibiting protein synthesis) and pharmacological blockade of non-NMDA-type glutamate receptors.
Measurement of GLR-1 glutamate receptor subunit expression levels.

Main Results:

Memory for habituation in C. elegans persists for 48 hours.
Heat shock and glutamate receptor blockade after memory recall impaired 48-hour retention.
GLR-1 expression decreased in trained animals after 48 hours, an effect reversed by heat shock post-recall.

Conclusions:

Memory reconsolidation is essential for long-term habituation memory in C. elegans.
Glutamate receptor activity, specifically GLR-1, is involved in memory reconsolidation.
Mechanisms impairing memory consolidation also disrupt reconsolidation, suggesting overlapping molecular pathways.