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Collagenous spherulosis in chondroid syringomas
1Department of Pathology, University of Iowa, Iowa City.
The American Journal of Dermatopathology
|April 1, 1991
Summary
Collagenous spherulosis (CS) was found in a facial skin chondroid syringoma. This finding suggests CS can occur outside the breast, associated with tubular structures.
Area of Science:
- Dermatopathology
- Histology
- Oncology
Background:
- Collagenous spherulosis (CS) is a rare finding typically associated with breast tissue.
- Chondroid syringoma is a benign skin adnexal tumor.
Observation:
- Collagenous spherulosis (CS) was incidentally identified within a chondroid syringoma of the facial skin.
- Microscopic examination revealed eosinophilic globules with fibrillary structures.
- Special stains and immunohistochemistry highlighted collagen and basal lamina-like material.
Findings:
- Collagenous spherulosis (CS) is not exclusive to the breast and can occur in chondroid syringomas.
- The spherules are composed of collagen fibers and associated with tubular epithelial structures.
- No evidence of myoepithelial differentiation was observed in the collagenous spherulosis.
Implications:
- This case expands the known locations for collagenous spherulosis (CS).
- The association with tubular structures warrants further investigation into the pathogenesis of CS.
- The etiology and clinical significance of collagenous spherulosis in skin tumors remain to be elucidated.