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Updated: Jul 18, 2026

State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Are routine cranial ultrasounds necessary in premature infants greater than 30 weeks gestation?
N Ja'Neice Harris1, Diana Palacio, Andrew Ginzel
1Division of Neonatology, University of Texas Medical Branch, Galveston, Texas, USA.
Insights
This study suggests limiting routine cranial ultrasounds (US) for premature infants. Screening may be appropriate for infants born at 30 weeks gestation or less, not all preterm infants.
Area of Science:
- Neonatal neurology
- Pediatric neuroimaging
Background:
- Current guidelines recommend routine cranial ultrasonography for preterm infants.
- The American Academy of Neurology and Child Neurology Society suggest screening at 7-14 days and 36-40 weeks postmenstrual age for infants <30 weeks gestation.
- This study evaluates the efficacy of these guidelines in infants born between 30-33 weeks gestation.
Purpose of the Study:
- To validate the existing practice parameter for screening cranial ultrasonography in preterm infants.
- To determine the number of clinically significant abnormal screening ultrasounds that might be missed with current guidelines.
- To assess the optimal gestational age cutoff for routine cranial ultrasound screening.
Main Methods:
- Retrospective study of 486 infants born between 30 to 33 weeks gestation.
- Analysis of screening cranial ultrasounds performed on these infants.
- Evaluation of rates of Grade III/IV intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL).
Main Results:
- Grade III/IV intraventricular hemorrhage (IVH) occurred in 0.8% of infants (30-31 weeks gestation).
- Periventricular leukomalacia (PVL) was diagnosed in 1.4% of infants.
- A significant trend toward fewer abnormal cranial ultrasounds was observed in infants from 30 to 33 weeks gestation (p=0.04).
- Infants with significant findings had identifiable risk factors or symptoms.
Conclusions:
- The study supports limiting routine screening cranial ultrasounds.
- The findings suggest that the gestational age cutoff for screening should be 30 weeks or less.
- Current screening protocols may be adjusted based on gestational age to optimize resource utilization and detection rates.
Abstract:
The purpose of this study was to validate the recommendation of the American Academy of Neurology and the Child Neurology Society that screening cranial ultrasonography be performed routinely on all infants of less than 30 weeks gestation at 7 to 14 days of age and again between 36 and 40 weeks postmenstrual age, and, by using this practice parameter, to determine the number of babies with a clinically significant abnormal screening cranial ultrasound (US) who would otherwise have been missed. A retrospective study of 486 infants of 30 to 33 weeks gestation born January 1, 1999 to June 30, 2004 was done. All had screening cranial ultrasounds. Grade III and/or grade IV intraventricular hemorrhage (IVH) occurred in 4 (0.8%) infants of 30 to 31 weeks gestation. Infants with significant IVH had either risk factors for brain injury or symptoms that would eventually warrant US during their hospitalization. Seven (1.4%) infants had periventricular leukomalacia (PVL). All infants with a final diagnosis of PVL had pre- and/or perinatal risk factors associated with PVL. There was a significant trend toward fewer abnormal cranial ultrasounds from 30 to 33 weeks gestation (p=0.04). Our study supports the recommendation by the American Academy of Neurology and the Child Neurology Society that screening US can be limited but suggests that the gestational age cut off should be 30 weeks or less.
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