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Updated: Jul 18, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
Published on: December 22, 2016
CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy
Suzanne D Turner1, Hartmut Merz, Debra Yeung
1Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, UK. Sdt36@cam.ac.uk
Background:
Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation.
Materials And Methods:
We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter.
Results:
Surprisingly, the mice develop B cell lymphomas in the majority of cases.
Conclusion:
These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype.
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