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Updated: Jul 18, 2026
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Effects of fibroblast growth factors 19 and 20 on cell multiplication and locomotion in a human embryonal carcinoma
Wilhelm Engström1, Marika Granerus
1Department of Biosciences and Veterinary Public Health, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden. wilhelm.engstrom@bvf.slu.se
Background:
The effects of two recently discovered heparin binding growth factors, FGF-19 and FGF-20, on the human embryonal carcinoma derived cell line Tera 2 were examined.
Materials And Methods:
Cell numbers, as well as cell migration were examined at the clonal level by light microscopy.
Results:
FGF-19, as well as FGF-20 promoted Tera 2 cell multiplication. Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect. Moreover, FGF-19 did not significantly stimulate cell locomotion, while FGF-20 promoted cell motility at high doses.
Conclusion:
FGF-19 and FGF-20 qualitatively exert different effects on cell survival and cell locomotion.
