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Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention

Nikolaus Seiler1, Mehdi Chaabi, Stamatiki Roussi

  • 1INSERM U682, Laboratory of Nutritional Cancer Prevention, IRCAD, 67091 Strasbourg, France. nikolaus.seiler@ircad.u-strasbg.fr

Anticancer Research
|November 11, 2006
PubMed
Abstract

Insights

Apple procyanidins show promise for colon cancer prevention. Combining them with lysosomotropic compounds enhances their anti-cancer effects by improving lysosomal function.

Area of Science:

  • Oncology
  • Pharmacology
  • Nutraceuticals

Background:

  • Procyanidins, found in apples, are investigated for their potential role in colon cancer chemoprevention.
  • Colon cancer remains a significant health concern, necessitating novel chemopreventive strategies.

Purpose of the Study:

  • To evaluate the synergistic effects of apple procyanidins and lysosomotropic compounds on colon cancer cells.
  • To determine the impact of these combinations on cancer cell growth, apoptosis, and lysosomal integrity.

Main Methods:

  • Human colon cancer metastatic cells (SW620) were treated with procyanidins and various lysosomotropic compounds.
  • Cell growth, apoptosis induction, and lysosomal membrane permeability were assessed using established methodologies.

Main Results:

  • Lysosomotropic drugs (MDL 72527, phenylalanine methylester, chloroquine) significantly enhanced procyanidin-induced growth inhibition and apoptosis in SW620 cells.
  • These synergistic effects were observed at non-cytotoxic concentrations of the lysosomotropic compounds.
  • The enhanced anti-cancer activity was primarily attributed to increased lysosomal membrane permeability.

Conclusions:

  • Combining non-toxic concentrations of lysosomotropic compounds with apple procyanidins potentiates their anti-carcinogenic properties.
  • This combination strategy offers a promising approach for enhancing the efficacy of procyanidin-based colon cancer chemoprevention.

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