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Lidocaine or diazepam can decrease fasciculation induced by succinylcholine during induction of anesthesia.

Mansour Hassani1, Mohammad Ali Sahraian

  • 1Tehran University of Medical Sciences, Hassan Abad Square, Sina Hospital, Tehran, Iran. msahrai@sina.tums.ac.ir

Middle East Journal of Anaesthesiology
|November 11, 2006
PubMed
Summary
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Succinylcholine can cause muscle fasciculations during anesthesia induction. Intravenous diazepam or lidocaine effectively reduces these fasciculations and prevents associated increases in blood pressure and heart rate.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Succinylcholine is a common neuromuscular blocking agent used in anesthesia induction.
  • Succinylcholine administration can lead to undesirable muscle fasciculations.
  • These fasciculations may be associated with hemodynamic changes such as elevated blood pressure and heart rate.

Purpose of the Study:

  • To evaluate the efficacy of intravenous diazepam and lidocaine in mitigating succinylcholine-induced fasciculations.
  • To assess the impact of these agents on hemodynamic responses during endotracheal intubation.

Main Methods:

  • A study involving intravenous administration of diazepam (1 mg/kg) or lidocaine (1.5 mg/kg) prior to succinylcholine.
  • Monitoring for the presence and severity of fasciculations.
  • Measurement of blood pressure and heart rate changes during intubation.

Related Experiment Videos

Main Results:

  • Both intravenous diazepam and lidocaine significantly decreased succinylcholine-induced fasciculations.
  • No significant difference was observed between diazepam and lidocaine in their fasciculation-reducing effects.
  • Both agents effectively prevented the rise in blood pressure and heart rate typically seen during intubation.

Conclusions:

  • Intravenous diazepam and lidocaine are effective premedications to reduce succinylcholine fasciculations.
  • These drugs offer a dual benefit by also attenuating hemodynamic stress during intubation.
  • Clinicians can consider using diazepam or lidocaine to improve patient comfort and safety during anesthesia induction.