Related Experiment Video
Updated: Jul 18, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Mid-term results of overlapping cardiac volume reduction for ischemic cardiomyopathy]
Y Ikeda1, R Suzuki, M Takahashi
1Department of Medical Bioregulation, Division of Cardiac Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan.
Insights
Overlapping cardiac volume reduction (OLCVR) is an effective surgical option for left ventricular restoration (LVR) in patients with ischemic cardiomyopathy (ICM). This procedure shows favorable early and mid-term results, improving cardiac function and patient outcomes.
Area of Science:
- Cardiology
- Cardiac Surgery
Context:
- Ischemic cardiomyopathy (ICM) often leads to left ventricular dysfunction.
- Left ventricular restoration (LVR) aims to improve heart function in these patients.
Purpose:
- To evaluate the early and mid-term outcomes of overlapping cardiac volume reduction (OLCVR) for LVR in patients with ICM.
Summary:
- Four patients with ICM underwent OLCVR. Postoperatively, significant reductions in left ventricular end-diastolic and end-systolic volumes were observed.
- These improvements persisted at 1-year follow-up, with enhanced New York Heart Association (NYHA) functional class and reduced left ventricular diastolic diameter.
- No deaths occurred; one patient required a cardioverter-defibrillator 16 months post-procedure.
Impact:
- OLCVR demonstrates promising early and mid-term efficacy for LVR in ICM patients.
- The procedure contributes to improved cardiac remodeling and functional capacity.
Background:
Left ventricular restoration (LVR) is thought to be effective for ischemic cardiomyopathy (ICM). We assessed the early and mid-term results of overlapping cardiac volume reduction (OLCVR) as an operation for LVR on patients with ICM.
Methods:
From February to June 2004, 4 patients with ICM underwent OLCVR in our department.
Results:
There was no death. Significant decreases in the left ventricular end diastolic volume index and in the left ventricular end systolic volume index were observed in the early postoperative period in all the 4 patients. These effects were still evident 1 year later, with improved New York Heart Association (NYHA) functional class and a smaller left ventricular diastolic diameter. One patient required implantation of a cardioverter defibrillator 16 months postoperatively.
Conclusion:
The favorable early and mid-term results of the OLCVR indicate that it is an effective procedure for patients with ICM.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Cardiomyopathy II: Dilated Cardiomyopathy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Mitral Stenosis I: Introduction
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
