Related Experiment Video
Updated: Jul 18, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course
C Vaklavas1, A Tefferi, J Butterfield
1Department of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Abstract:
In a study of 99 consecutive patients with "idiopathic" eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (approximately 8%) with an "Occult" T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.
Related Concept Videos
Amebiasis
Giardiasis
Asthma I: Introduction
Toxoplasmosis
Atypical Pneumonia
American Trypanosomiasis