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Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER
Gilles D Tamagnan1, Eric Brenner, David Alagille
1Institute for Degenerative Diseases, New Haven, CT 06520, USA. gtamagnan@indd.org
Abstract:
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging.
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