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Regulation of glucocorticoid receptor expression
S Okret1, Y Dong, M Brönnegård
1Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden.
Biochimie
|January 1, 1991
Summary
Cell sensitivity to glucocorticoid hormones depends on intracellular glucocorticoid receptor (GR) levels. This study explores GR autoregulation, cAMP effects, and GR expression during fetal rat lung development.
Area of Science:
- Molecular Endocrinology
- Cellular Biology
- Hormone Signaling
Background:
- Intracellular glucocorticoid receptor (GR) concentration is critical for cellular sensitivity to glucocorticoid hormones.
- Cells regulate GR expression to adapt to hormonal changes and biological response demands.
- GR expression is a complex process involving transcriptional and posttranscriptional mechanisms.
Purpose of the Study:
- To investigate the complex regulation of glucocorticoid receptor (GR) expression.
- To examine GR autoregulation, the impact of cAMP, and GR expression during fetal rat lung development.
Main Methods:
- Analysis of transcriptional and posttranscriptional regulatory mechanisms of GR expression.
- Investigation of factors acting through second messenger pathways to modulate GR levels.
- Comparative studies of GR expression under various physiological conditions.
Main Results:
- GR expression is tightly regulated, adapting cellular sensitivity to glucocorticoids.
- Autoregulation of GR influences its own expression levels.
- cAMP significantly affects GR expression, indicating integration into cellular signaling networks.
- GR expression patterns during fetal rat lung development were characterized.
Conclusions:
- Cellular adaptation to glucocorticoids is achieved through dynamic regulation of intracellular GR concentration.
- Complex hormonal networks, including cAMP signaling, control glucocorticoid-regulated gene expression.
- Understanding GR regulation is key to comprehending cellular responses to hormonal stimuli.