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Related Experiment Video

Updated: Jul 18, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Concurrent strength and endurance training: from molecules to man.

Gustavo A Nader¹

¹Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA. gnader@cnmcresearch.org

Medicine and Science in Sports and Exercise

|November 11, 2006

Summary

Concurrent training, or performing strength and endurance exercise simultaneously, can hinder strength gains. This interference may stem from conflicting molecular signals within muscle cells, impacting muscle adaptation and growth.

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Area of Science:

Exercise physiology
Molecular biology
Sports science

Background:

Strength training enhances muscle mass and strength.
Endurance training improves maximal oxygen uptake and exercise capacity.
Concurrent training, combining both, can lead to interference in strength development.

Purpose of the Study:

To review the phenomenon of concurrent training.
To examine molecular mechanisms behind strength development interference.
To understand the impact of combined exercise on muscle adaptation.

Main Methods:

Literature review of concurrent training studies.
Analysis of molecular signaling pathways in muscle.
Examination of antagonistic intracellular signaling mechanisms.

Main Results:

Concurrent training can inhibit strength adaptations.
Endurance exercise activates AMPK, which may inhibit mTOR signaling.
Conflicting molecular signals can negatively impact muscle adaptive responses.

Conclusions:

The interference effect in concurrent training has molecular underpinnings.
AMPK activation by endurance exercise can inhibit protein synthesis pathways.
Understanding these molecular mechanisms is key to optimizing concurrent training strategies.