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10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Venous thromboembolic disease: a single-centre case series study.
Fiona Newall1, Tim Wallace, Catherine Crock
1Department of Clinical Haematology, Royal Children's Hospital, Parkville, Victoria, Australia.
Journal of Paediatrics and Child Health
|November 14, 2006
Summary
Pediatric venous thromboembolism (VTE) is more frequent than previously reported, with central venous catheterization a common cause. Long-term complications remain a concern, highlighting the need for optimized diagnosis and treatment in children.
Area of Science:
- Pediatrics
- Hematology
- Epidemiology
Background:
- Venous thromboembolism (VTE) epidemiology in children evolves due to changing management and increased awareness of risk factors.
- Previous VTE data in pediatric populations may not reflect current trends.
Purpose of the Study:
- To determine the current epidemiology of VTE in Australian infants and children.
- To assess the prevalence, causes, diagnosis, management, and outcomes of pediatric VTE.
Main Methods:
- A prospective, single-center registry of pediatric venous thrombosis was established.
- Data collected included incidence, patient demographics, predisposing factors, diagnostic methods, treatments, and outcomes.
Main Results:
- The incidence of VTE was 8.0 per 10,000 hospital admissions.
- Central venous cannulation was a frequent precipitant, especially in infants (77%) compared to children (47%).
- Mortality was 8.4%, with 15% experiencing significant long-term morbidity.
Conclusions:
- Pediatric VTE occurs more frequently than previously reported, with varied epidemiology.
- Central venous catheterization remains a significant risk factor.
- Optimal diagnostic and treatment strategies for pediatric VTE require further determination due to long-term sequelae.
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