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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

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Venous thromboembolic disease: a single-centre case series study.

Fiona Newall¹, Tim Wallace, Catherine Crock

¹Department of Clinical Haematology, Royal Children's Hospital, Parkville, Victoria, Australia.

Journal of Paediatrics and Child Health

|November 14, 2006

Summary

Pediatric venous thromboembolism (VTE) is more frequent than previously reported, with central venous catheterization a common cause. Long-term complications remain a concern, highlighting the need for optimized diagnosis and treatment in children.

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Area of Science:

Pediatrics
Hematology
Epidemiology

Background:

Venous thromboembolism (VTE) epidemiology in children evolves due to changing management and increased awareness of risk factors.
Previous VTE data in pediatric populations may not reflect current trends.

Purpose of the Study:

To determine the current epidemiology of VTE in Australian infants and children.
To assess the prevalence, causes, diagnosis, management, and outcomes of pediatric VTE.

Main Methods:

A prospective, single-center registry of pediatric venous thrombosis was established.
Data collected included incidence, patient demographics, predisposing factors, diagnostic methods, treatments, and outcomes.

Main Results:

The incidence of VTE was 8.0 per 10,000 hospital admissions.
Central venous cannulation was a frequent precipitant, especially in infants (77%) compared to children (47%).
Mortality was 8.4%, with 15% experiencing significant long-term morbidity.

Conclusions:

Pediatric VTE occurs more frequently than previously reported, with varied epidemiology.
Central venous catheterization remains a significant risk factor.
Optimal diagnostic and treatment strategies for pediatric VTE require further determination due to long-term sequelae.