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Related Experiment Videos

Primary colonic malignant melanoma.

Daisuke Mori1, Toshimi Satoh, Yuji Nakafusa

  • 1Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Saga, Japan. mori-d@koseikan.jp

Pathology International
|November 14, 2006
PubMed
Summary

Primary malignant melanoma of the colon is exceptionally rare. This case highlights a unique instance of colonic melanoma, successfully treated with surgery, emphasizing the need for careful differential diagnosis.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Primary malignant melanoma in the digestive tract is a rare clinical entity.
  • Distinguishing primary colonic melanoma from metastatic disease is diagnostically challenging.

Observation:

  • A case of primary malignant melanoma in the descending colon presented as an elevated mass with surface necrosis.
  • Histological examination revealed tumor cells with pleomorphic nuclei and rich cytoplasm, some with a signet ring-like appearance.
  • Immunohistochemical analysis confirmed melanoma markers (S-100, HMB-45, melan-A) and ultrastructural findings showed premelanosomes.

Findings:

  • The tumor was diagnosed as primary colonic malignant melanoma due to the absence of cutaneous or ocular primary sites.
  • The patient remained disease-free for 3 years post-surgical resection.

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  • EWS-ATF-1 fusion transcript, associated with clear cell sarcoma, was notably absent.

    • Implications:

    • Accurate differentiation of primary colonic melanoma from other intestinal tumors and metastases is crucial for appropriate patient management.
    • This case underscores the importance of thorough diagnostic workup for rare gastrointestinal malignancies.
    • Successful surgical management offers a positive prognosis for primary colonic melanoma.