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Updated: Jul 18, 2026

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
Tube weaning according to the Graz model in two children with Alagille syndrome
K Burmucic1, T Trabi, A Deutschmann
1Medical University of Graz, University Hospital for Children, Department of General Pediatrics, Psychosomatic and Psychotherapeutic Unit, Graz, Austria. katharina.burmucic@klinikum-graz.at
Insights
Children with Alagille syndrome successfully transitioned from long-term tube feeding after liver transplant. This intensive protocol rapidly restored normal feeding behaviors and body weight, improving quality of life.
Area of Science:
- Pediatric Gastroenterology
- Hepatology
- Transplant Surgery
Background:
- Long-term enteral tube feeding is common in children with Alagille syndrome post-liver transplant.
- Alagille syndrome can significantly impair oral feeding abilities.
- Prolonged tube dependence may lead to complications and reduced quality of life.
Observation:
- Two pediatric patients with Alagille syndrome, dependent on long-term tube feeding post-liver transplant, were enrolled in a specialized weaning protocol.
- The protocol focused on intensive, structured interventions to encourage oral intake.
- Close monitoring of feeding behavior and weight stabilization was maintained.
Findings:
- Both children were successfully weaned from enteral tube feeding within 7 and 13 days, respectively.
- Normal feeding behavior was re-established in both patients.
- Stable body weight was achieved, indicating successful nutritional rehabilitation.
Implications:
- Even prolonged enteral tube dependence in children with Alagille syndrome post-liver transplant is reversible.
- Early introduction of age-appropriate self-feeding is crucial.
- This brief and effective weaning program can be widely adopted to enhance patient quality of life and minimize enteral feeding side-effects.
Abstract:
Two children were weaned from long-term tube feeding after liver transplant because of Alagille syndrome. The children were successfully weaned, one in seven days and the other in 13 days, using our standard and highly specialized intensive treatment protocol. Normal feeding behavior and stabilization of body weight were established. Children fed by long-term enteral tubes can be weaned from enteral feeding even after a long period of treatment. The return to age-appropriate self-feeding should be introduced as early as possible. Our weaning program time is brief and effective and can be recommended generally to improve quality of life and withhold unintended side-effects of enteral nutrition.
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