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[Platelet and tissue factor: review].

Jie Chen1, Jing-Ye Pan

  • 1ICU, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|November 14, 2006
PubMed
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Platelets release tissue factor, a key factor in blood clot formation. This review details how platelets interact with tissue factor, influencing coagulation and thrombosis.

Area of Science:

  • Biochemistry
  • Hematology
  • Cell Biology

Background:

  • Tissue factor (TF) is crucial for coagulation and intravascular thrombus formation.
  • TF is expressed on circulating monocytes, induced by endotoxin.
  • Platelet surface receptors (P-selectin, CD40 ligand, GPIIb/IIIa) can modulate monocyte TF expression.

Purpose of the Study:

  • To review the intricate relationship between platelets and tissue factor.
  • To elucidate the role of platelet-derived tissue factor in hemostasis and thrombosis.

Main Methods:

  • Literature review of studies on tissue factor and platelet interactions.
  • Analysis of research on monocyte TF expression modulation by platelet components.
  • Examination of evidence for TF presence and release from circulating platelets.

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Main Results:

  • Platelets contain and can release tissue factor into circulation.
  • Platelet-derived TF can initiate the coagulation cascade.
  • Platelet surface molecules influence TF expression on monocytes.

Conclusions:

  • Platelets are a significant source of tissue factor, impacting coagulation.
  • Understanding platelet-TF interactions is vital for managing thrombotic disorders.
  • Further research into platelet TF release mechanisms is warranted.