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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
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[Platelet and tissue factor: review]

Jie Chen1, Jing-Ye Pan

  • 1ICU, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|November 14, 2006
PubMed

It is generally accepted that tissue factor plays an important role in coagulation and intravascular thrombus formation. Tissue factor is not only found primarily on the surface of certain cells that are located outside the vasculature, but also found in circulating cells. Monocyte express tissue factor induced by endotoxin. Recently, many researches indicate that P-selectin, CD40 ligand and GPIIb/IIIa receptor of platelet can also affect expression of tissue factor by monocyters. In addition, a lot of studies showed that tissue factor exist in the circulation including contained platelet. Tissue factor in the platelet releases under certain condition, and initiates coagulation. In this review the relation between platelet and tissue factor was elaborated.

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