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Related Experiment Video

Updated: Jul 18, 2026

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Published on: July 6, 2011

Striatal function in generalized social phobia: a functional magnetic resonance imaging study.

Jitender Sareen¹, Darren W Campbell, William D Leslie

¹Department of Psychiatry, University of Manitoba, Winnipeg, Canada. sareen@cc.umanitoba.ca

Biological Psychiatry

|November 14, 2006

Summary

Generalized social phobia (GSP) is linked to striatal dysfunction, indicated by reduced brain activation in key areas during a cognitive task. This study highlights neurobiological differences in GSP patients compared to healthy individuals.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Generalized social phobia (GSP) is associated with amygdala involvement, but other neural regions remain understudied.
Altered dopaminergic functioning in GSP suggests potential striatal dysfunction.
This is the first fMRI study to investigate GSP using a striatum-engaging cognitive task.

Purpose of the Study:

To examine neural correlates of GSP using functional magnetic resonance imaging (fMRI).
To compare striatal activation in GSP subjects versus healthy controls during a cognitive task.
To investigate the role of the striatum in the neurobiology of GSP.

Main Methods:

fMRI was used to scan 10 unmedicated GSP subjects and 10 healthy controls.
Participants performed an implicit sequence learning task known to activate striatal regions.
Subjects were matched for age, gender, and education.

Main Results:

Behavioral performance on the task did not differ significantly between GSP and control groups.
GSP subjects showed significantly reduced neural activation in the left caudate head, left inferior parietal lobe, and bilateral insula.
These regions are associated with implicit learning and striatal function.

Conclusions:

Findings support the hypothesis linking GSP to striatal dysfunction.
The study advances the neurobiological understanding of GSP.
Reduced activation in specific brain regions offers insights into the mechanisms of GSP.