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Updated: Jul 18, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Saccade-related potentials recorded from human subthalamic nucleus.

Adrian P Fawcett¹, Daniel Cunic, Clement Hamani

¹Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|November 14, 2006

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The subthalamic nucleus (STN) plays a role in eye movement control in Parkinson's disease (PD) patients. These findings suggest a shared mechanism for motor preparation in the basal ganglia for both eye and limb movements.

Area of Science:

Neuroscience
Movement Disorders
Motor Control

Background:

Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
The subthalamic nucleus (STN) is a key component of the basal ganglia motor circuit.
The precise role of the STN in ocular motor control remains incompletely understood.

Purpose of the Study:

To investigate the role of the STN in ocular motor control in PD patients.
To identify premovement potentials associated with saccadic eye movements in the STN.

Main Methods:

Deep brain stimulation (DBS) electrodes were implanted near the STN in five PD patients.
Electrophysiological potentials were recorded during visually cued and self-paced saccades.
In two patients, potentials during self-paced wrist extensions were also recorded for comparison.

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Main Results:

Premovement potentials related to visually cued saccades were observed in 4/5 patients, with some indicating a local generator within the STN.
Potentials associated with self-paced saccades were found in all tested patients (4/4).
Onset times of these potentials suggest a role for the STN in motor preparation for both eye and limb movements, with potential common mechanisms.

Conclusions:

The STN is implicated in the generation of premovement potentials during saccadic eye movements in PD.
These findings suggest that the STN contributes to ocular motor control.
A common neural mechanism for motor preparation of eye and limb movements may exist within the basal ganglia.