Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple calcified subungual epidermoid inclusions.

Gladys H Telang1, Nathaniel Jellinek

  • 1Department of Dermatology, Brown Medical School, Providence, RI 02903, USA.

Journal of the American Academy of Dermatology
|November 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative management in nail surgery: An international Delphi consensus statement.

Journal of the American Academy of Dermatology·2026
Same author

Nail unit squamous cell carcinoma: A multicenter, retrospective study of the clinical and morphologic characteristics of 261 patients.

Journal of the American Academy of Dermatology·2026
Same author

Modern definitions of periungual pigmentation (Hutchinson sign): Results of an expert opinion consensus conference.

Journal of the American Academy of Dermatology·2025
Same author

Painless Nodule on the Lower Eyelid.

Cutis·2025
Same author

Pincer Nail in All 20 Nails in a Patient on Selective RET Inhibitor Selpercatinib Treated With Partial Avulsion and Matricectomy.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2025
Same author

Evaluation and diagnosis of longitudinal melanonychia: A clinical review by a nail expert group.

Journal of the American Academy of Dermatology·2025

Subungual epidermoid inclusions are rare nail abnormalities. This case highlights their potential underdiagnosis and the importance of adequate biopsies for persistent nail disorders.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Subungual epidermoid inclusions (SEIs), or subungual onycholemmal cysts, are uncommon nail bed abnormalities.
  • Clinical presentation can vary, including onychodystrophy, thickening, or normal nail appearance.

Observation:

  • A case of a 7-year-old patient with persistent right hallux onychodystrophy is presented.
  • Serial images documented progressive nail thickening, yellow discoloration, and nail bed hyperkeratosis.

Findings:

  • Initial treatments for fungal infections were ineffective, and a superficial biopsy was nondiagnostic.
  • A repeat full-thickness nail bed biopsy revealed calcified SEIs with characteristic histologic features.
  • Histology showed rete ridge elongation, cyst formation with onycholemmal keratin, and calcification.

Related Experiment Videos

Implications:

  • This case underscores the need for thorough clinical reassessment and sufficient biopsy in undiagnosed nail unit disorders.
  • Subungual calcified inclusions may be a more common entity than currently recognized, potentially aiding diagnosis.