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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Comparison of two formulations of botulinum toxin type A for the treatment of glabellar lines: a double-blind,
Philippa Lowe1, Rickie Patnaik, Nicholas Lowe
1Cranley Clinic, London, United Kingdom.
Background:
Different formulations of botulinum toxin type A can behave differently. There has been little clinical research directly comparing formulations.
Objective:
We sought to compare the efficacy and tolerability of two botulinum toxin type A formulations-BoNTA1 and BoNTA2-in the treatment of moderate and severe glabellar lines.
Methods:
Sixty-two patients with moderate or severe glabellar lines at maximum contraction were randomly assigned to receive 20 U of BoNTA1 or 50 U of BoNTA2 (20% in the procerus muscle, 80% in the corrugator muscles).
Results:
The incidence of 1-grade improvement or greater in glabellar line severity at maximum contraction was as follows: 77% (BoNTA1) versus 59% (BoNTA2) at week 12, 53% versus 28% at week 16. The estimated incidence of relapse was 23% (BoNTA1) versus 40% (BoNTA2) at week 16. Both formulations were similarly well tolerated.
Limitations:
Few male and non-Caucasian subjects were studied.
Conclusion:
BoNTA(1) offered more prolonged efficacy than BoNTA2 in the treatment of glabellar lines at the dose ratio of 2.5:1 (BoNTA2:BoNTA1) used in this study.
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