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Voxel-based morphometry in autopsy proven PSP and CBD.

Keith A Josephs1, Jennifer L Whitwell, Dennis W Dickson

  • 1Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN 55905, USA. josephs.keith@mayo.edu

Neurobiology of Aging
|November 14, 2006
PubMed
Summary

MRI reveals distinct brain atrophy patterns in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). These differences help distinguish between PSP and CBD, aiding in diagnosis based on clinical syndromes.

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Neurodegenerative Diseases

Background:

  • Distinguishing between progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is crucial for accurate diagnosis and management.
  • Both PSP and CBD are atypical parkinsonian disorders characterized by progressive neurodegeneration.
  • Understanding in vivo patterns of brain atrophy can aid in differentiating these conditions.

Purpose of the Study:

  • To compare magnetic resonance imaging (MRI) patterns of grey and white matter atrophy in autopsy-confirmed PSP and CBD.
  • To investigate if atrophy patterns differ based on dominant clinical syndromes (dementia vs. extrapyramidal).
  • To correlate in vivo imaging findings with neuropathological diagnoses.

Main Methods:

  • Voxel-based morphometry (VBM) analysis of MRI scans.
  • Comparison of 13 PSP subjects, 11 CBD subjects, and 24 healthy controls.
  • Subgroup analysis based on clinical presentation: dementia syndrome or extrapyramidal syndrome.

Main Results:

  • Progressive supranuclear palsy (PSP) subjects exhibited brainstem atrophy with cortical and white matter involvement.
  • Corticobasal degeneration (CBD) subjects showed frontoparietal grey matter and subcortical grey matter atrophy.
  • Subgroup analysis revealed PSP with extrapyramidal syndrome had more brainstem atrophy than CBD with extrapyramidal syndrome.
  • PSP with dementia syndrome showed more subcortical white matter atrophy than CBD with dementia syndrome.

Conclusions:

  • Distinct regional atrophy patterns observed on MRI can help differentiate between PSP and CBD.
  • Clinical syndromes influence the distribution of atrophy in PSP and CBD.
  • These findings contribute to understanding the in vivo neuropathological correlates of PSP and CBD.