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Updated: Jul 18, 2026
Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
Published on: August 26, 2017
Direct visualization of neo-vessel formation following peripheral injection of bone marrow derived CD34+ cells in
M M Ciulla1, S Ferrero, U Gianelli
1Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza, 35-20122 Milano, Italy. michele.ciulla@unimi.it
Abstract:
The definitive fate of peripherally injected PKH26 labelled bone marrow mononuclear cells expressing the CD34+ antigen following experimental myocardial cryodamage in rats (n=10) has been examined by direct visualization on photoconverted light and electron microscopy images. One week after the injection in each rat of about 150,000 CD34+ cells early stage PKH26+ vascular structures were localized in the infarcted areas, suggesting that a potential benefit of this therapeutic approach consists in the regeneration of the vasculature.
