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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Microstructural white matter abnormalities in nodular heterotopia with overlying polymicrogyria.

Leonardo Bonilha¹, Jonathan Halford, Chris Rorden

¹Department of Neuropsychiatry, University of South Carolina, USA. bonilha@gwm.sc.edu

|November 14, 2006

Summary

Nodular heterotopia (NH) with polymicrogyria causes difficult-to-control seizures. Impaired white matter connectivity, not just abnormal cortex, contributes to functional deficits in patients with NH.

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Area of Science:

Neuroscience
Neurology
Medical Imaging

Background:

Nodular heterotopia (NH) with polymicrogyria often leads to medically refractory epilepsy.
Functional deficits correlate with the location of abnormal cortical development.
The functional capacity and connectivity of abnormal cortex in NH remain unclear, complicating surgical planning.

Observation:

This study investigated white matter microstructural integrity using diffusion evaluation in a patient with epilepsy due to NH and polymicrogyria.
The white matter subjacent to the polymicrogyric cortex exhibited abnormalities in its microstructure.

Findings:

The microstructural abnormalities in the underlying white matter suggest impaired connectivity associated with polymicrogyria.
These findings indicate that functional deficits in NH with polymicrogyria stem from both cortical malformation and disrupted white matter pathways.

Implications:

Understanding white matter connectivity is crucial for assessing functional deficits in patients with NH.
This research may inform surgical strategies by highlighting the role of connectivity in neurological impairments.
Further studies on white matter integrity can improve prognostication and treatment planning for epilepsy associated with cortical malformations.