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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Steroids and bone density in patients with functioning kidney allografts.
1Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain. rgalsam@gobiernodecanarias.org
Transplantation Proceedings
|November 14, 2006
Summary
Osteopenia and osteoporosis are common after kidney transplants, affecting 66% of patients. Maintaining a healthy weight and good kidney function may help protect bone density in transplant recipients.
Area of Science:
- Nephrology
- Endocrinology
- Orthopedics
Background:
- Osteopenia and osteoporosis are common complications following renal transplantation.
- Factors contributing to end-stage renal disease and post-transplant events influence bone health.
- Prevalence of low bone density (LBD) was assessed using World Health Organization (WHO) criteria.
Purpose of the Study:
- To determine the prevalence of low bone density (LBD) in patients with functioning renal allografts.
- To identify clinical, analytical, and therapeutic factors associated with LBD post-transplantation.
Main Methods:
- A cross-sectional study involving 106 renal transplant recipients with functioning allografts.
- Bone densitometry (DEXA) was performed on the lumbar spine and femoral neck.
- Patients were categorized into normal bone density (NBD) and low bone density (LBD) groups.
Main Results:
- 66% of patients exhibited low bone density (LBD).
- Higher body weight was significantly associated with normal bone density (P = .034).
- Lower creatinine clearance (CCr) and higher parathyroid hormone (PTHi) levels tended to be associated with LBD (P = .052 and P = .069, respectively).
Conclusions:
- Osteopenia and osteoporosis are highly prevalent (66%) in kidney transplant recipients.
- Excess weight and better renal function may be protective against LBD.
- Secondary hyperparathyroidism is a risk factor for LBD, while cumulative steroid dose significantly impacts bone density.
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